LaDainian Tomlinson rushed for a career- high four touchdowns and Philip Rivers passed for two scores as the San Diego Chargers hammered the San Francisco 49ers, 48-19, at Monster Park.

Tomlinson had 71 rushing yards on 21 carries and Rivers was 29-of-39 passing for a career-high 334 yards in the win.

Antonio Gates added five catches for 78 yards and a score, while Vincent Jackson grabbed a 33-yard touchdown reception for San Diego (4-1), which travels to Kansas City to play the Chiefs on October 22.

Alex Smith was 20-of-31 passing 214 yards with two touchdowns and an interception for the 49ers (2-4), who will have a bye next weekend. Moran Morris and Bryan Gilmore chipped in with touchdown catches.

The Chargers got out of the gate early and often. Rivers threw a screen pass to Antonio Gates, who went the distance scoring on a 57-yard catch and run on San Diego’s first offensive possession of the contest, giving them an early 7-0 lead. Rivers was 3-of-4 passing on the six-play, 78-yard scoring drive.

However, the 49ers wasted little time answering on their first offensive try. Starting on their own 26, Smith hooked up with Antonio Bryant on a 15-yard pass play and three plays later Frank Gore ran one around the left end for a 22-yard gain. Smith connected with Gilmore for a 15-yard touchdown to even the score at 7-7.

The wild opening quarter continued when the Chargers put up another seven points on their second offensive series, going 91-yards on 11-plays led by Rivers, who hit on all four of his pass attempts. Tomlinson finalized the series with a five-yard scoring run around the right end.

San Francisco answered again with points on their second offensive series of the contest. Smith completed passes of 25 and 16 yards, but the drive fizzled and the Niners had to settle for a Joe Nedney 42-yard field goal, closing the lead to 14-10 early in the second quarter.

San Diego’s offensive barrage continued on their third series, adding yet another seven points. Rivers hooked up with Jackson for a 33-yard score, capping a five-play, 77-yard scoring drive to put the Bolts ahead 21-10 with just over 12 minutes left in the second stanza.

After a three and out by the 49ers offense, the Chargers continued to pile up the points. With Rivers completing 4-of-4 passes, he led San Diego into the end zone again, with Tomlinson running one in over left tackle from a yard out to make it 28-10.

The 49ers had an answer on the next offensive series, putting together a well orchestrated drive that was finished off when Smith hit Morris for a two-yard TD, to cut the Chargers deficit to 28-17.

San Francisco added another two points on the Bolts’ next series. Starting on their own six yard line due to an illegal block on the kickoff, Rivers dropped back into his own end zone and threw an incomplete pass against heavy pressure. The officials ruled Rivers intentionally grounded the ball, awarding the Niners with a safety.

However, that would be the last time San Francisco scored in the game.

Following an interception by San Diego defensive end Luis Castillo at the 49ers 35 with just over three minutes remaining in the first half, the Chargers’ offense wasn’t finished. Tomlinson capped off a nine-play, 35-yard scoring drive with another one-yard run for his third score of the half, giving the Chargers a comfortable 35-19 lead heading into the intermission.

The San Diego offensive picked up right where it left off in the third quarter. After the defense shut down the Niners’ offense with a three and out, the Chargers tacked on another field goal when Nate Kaeding split the uprights from 24 yards out to make it 38-19.

After the teams traded several punts, Kaeding added a 44-yard field goal, his second of the contest to finalize a seven-play, 38-yard set.

Tomlinson scored his fourth touchdown of the contest on a five-yard run late in the final quarter to finish off a 13-play, 56-yard drive and make the score 48-19.