The 49ers travel to Arizona this weekend to kick off their regular season. Everyone and their grandmother is predicting the Cardinals to christen Arizona Stadium with a win, including me. I hate to admit it but the cards – no pun intended – are not in the 49ers favor. Here is a breakdown of what to expect when each unit has the ball.

When the 49ers have the ball:
Arizona will stack eight in the box, forcing Alex Smith to beat them in the air. I expect the offense to look like it did against the Bears in the preseason opener, with more roll-outs, play action, and bootlegs. I’m not to concerned with the passing game at this time, due to the fact, that Frank Gore will find a way to get his yards. Just when you think Gore is stopped he fights for those few extra yards. Throw in rookie Michael Robinson and change of pace back Maurice Hicks and the 49ers running game will do just fine. This will open up the play action and if Smith can avoid turnovers and spread the ball around, this should keep the Cardinals defense honest. In order for the 49ers to win this game, they’ll have to win it on the ground.

[49ers Victory Not in the Cards] – 49ersNews on NFL Fanhouse